iCell Gene Therapeutics is proud to announce the publication of our preclinical CD4CAR T-cell data in Leukemia, a leading hematology-oncology journal. In our article, "Preclinical targeting of human T cell malignancies using CD4-specific chimeric antigen receptor (CAR)-engineered T cells" we demonstrate the efficacy of our CAR technology for the targeting of human CD4 positive T-cell malignancies in blood samples obtained from patients with currently incurable disease. Our study is unique in that it is among the first CAR therapy studies focused on T-cell malignancies, a subset of cancers with poor prognosis and few treatment options for many patients. We are grateful for the opportunity to contribute to the science of CAR therapy, with the long-term goal of enhanced patient outcomes. As a result of our research team’s findings, we are now one step closer to bringing curative CAR therapy to patients with relapsing or resistant T-cell malignancies. You can read more about our study on Leukemia’s website.


Although our preclinical data has been validated rigorously as effective in an experimental setting, the safety of our CD4CAR T-cell therapy has not been determined in humans. There are significant known and unknown risks and uncertainties associated with the development of a therapy such as this one. Should one or more of these risks or uncertainties materialize, actual clinical outcomes may differ significantly from those expected by our team, and may not allow for the curative option that we are hoping will be the end result of our preclinical and clinical work.



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